Disease Areas

We are currently studying itolizumab in a number of clinical trials in diseases where immuno-inflammation plays a role, including graft-versus-host disease, uncontrolled moderate to severe asthma, and SLE / lupus nephritis. By restoring the balance of T cells in the immune system, we hope to restore the balance of life for patients in need.

Link to: Graft-Versus-Host Disease


HSCT provides a potentially curative option for some types of cancer, but it comes with the risk of GVHD. GVHD occurs when the transplanted immune system attacks the recipient’s body and is the leading cause of non-cancer death in stem cell transplant recipients.

Link to: Lupus Nephritis

Lupus Nephritis

Lupus nephritis is among the most serious complications of SLE, occurring in 30 – 60% of individuals with SLE. In lupus nephritis, the body’s own immune system attacks the kidneys, causing inflammation and significantly reducing kidney function over time.

Link to: Uncontrolled Moderate to Severe Asthma

Uncontrolled Moderate to Severe Asthma

Individuals with asthma live with constant airway inflammation. Certain environmental triggers, exercise or illness can cause even more swelling and constriction of the muscles around the airway, making it difficult to breath.